The Future of Bioprinting is here
BiogelxTM has launched a new range of bioinks which are optimized for use in 3D bioprinting and maintain all the benefits of our standard range of products. The BiogelxTM Inks are composed of synthetic peptide hydrogels which form a nanofibrous network, mimicking the extracellular-matrix which supports cell growth, signaling, and proliferation. Our new generation bio-inks have applications in fundamental cell research, toxicology, and drug screening, and may ultimately be translated to cell therapy or regenerative medicine
Development of the new Biogelx Bioinks
The BiogelxTM peptide-based hydrogels were ideal starting points for the development of our new range of bioinks. These materials were found to exhibit shear-thinning properties, which reduce the shear stress experienced by cells when they are subjected to the printing process. Furthermore, the BiogelxTM Bioinks are printable at room temperature and do not require exposure to UV light, extreme temperature or pH changes, which can be detrimental to the health and viability of the cell culture. Thanks to the mild conditions required for gelation and the tunable viscosity of our base material, the new Bioink formulations offer excellent printability under biocompatible conditions.
We offer ability to balance printability with cell viability
The advantage of using synthetic hydrogels for bioprinting is that they can be tailored to specific applications. Biogelx’s simple peptide-based hydrogels provide a biocompatible environment with tunable mechanical properties, offering the ability to balance printability with cell viability. Biogelx Bioinks can be printed into air with good 3D fidelity and do not require the use of support, sacrificial or curing inks.
- Printability– Biogelx Bioinks have been developed for use in extrusion-based printing techniques. However, thanks to the tunable mechanical properties of the base material, these can also be optimized for use in other printing technologies.
- Biocompatibility – Our products are composed of bio-relevant amino-acids, are >95% water and produce a nanoscale matrix structure which mimics the natural extracellular matrix (ECM).
- Material Biomimicry – The Biogelx Bioink range includes formulations which incorporate a range of biomimetic peptide sequences, enhancing the biocompatibility of the materials with various cell types.
- Gelation time – Our product has been formulated to allow printing of a stable 3D structure into air. The printed structure maintains good 3D fidelity, and can be further cross-linked after printing by addition of cell culture media.
High Potential in Regenerative Medicine
Our Bioinks offer a 3D platform which could be used to print undifferentiated stem cells for application in the design of patient-specific therapies, whereby a patient’s own stem cells could be used to aid tissue repair and treat disease. In addition to such regenerative medicine techniques, 3D bioprinting of functional tissue constructs could be used in high-throughput in vitro tissue models for research, drug discovery, and toxicology.
Clearly, the impact on in vitro cell-based toxicology testing and in vivo regenerative medicine techniques will enhance the health and quality of life of patients with a wide variety of medical conditions. In addition, the ethical and cost benefits associated with an increase in the use of bioprinted tissue mimics, and therefore a reduction of animal testing will have a major societal benefit.