The advantages of peptide hydrogels over other 3D cell culture matrices.2 Comments
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Cell culture is an essential tool for the study of cell biology and preclinical biomedical research and has become a vital component of drug screening and toxicity testing in pharmacology research. Over recent years it has been widely acknowledged that 3D cell culture techniques can provide more physiologically-relevant results to more traditional 2D culture systems.
Cell culture models utilising 3D matrices allow individual cells to maintain their normal morphology, allow complex cell-cell and cell-matrix interactions, and provides oxygen and nutrient gradients, thereby providing an environment which more closely mimics the natural ECM, promoting the creation of native architecture found in vivo. Such matrices often take the form of hydrogels.
Hydrogels are water-swollen networks of crosslinked polymeric chains (up to 99% water) and have emerged as the most promising option for cell culture since they mimic salient elements of native ECMs and possess mechanics similar to those of many soft tissues.
In this context, both natural and synthetic hydrogels have been investigated extensively for the encapsulation and culture of cells, with both classes providing their own set of advantages and limitations. To achieve the best of both worlds, researchers are turning their attention to synthetic peptide hydrogels as 3D cell culture matrices where a balance of biocompatibility and consistency are possible.
Watch this webinar and learn:
- How our synthetic peptide hydrogels can provide a more physiologically relevant environment in vitro.
- How our 3D hydrogels can be tailored to control cell behaviour
- The potential of synthetic peptide hydrogels in applications including cancer research, cell-based assays, and regenerative medicine.
Robert Edward Schwartz, M.D., Ph.D.
Assistant Professor of Medicine at the Sanford I. Weill Medical College of Cornell University and an Attending Physician, New York-Presbyterian Hospital Cornell campus
Professor Matthew Dalby
Professor of Cell Engineering (Institute of Molecular Cell and Systems Biology) at the University of Glasgow
Chief Executive Officer of Biogelx Limited, former Sales & Marketing Director of Sartorius Stedim BioOutsource, and former Head of Sales & Marketing at Millipore UK