New generation RGD functionalised bioink from Biogelx


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Arginylglycylaspartic acid (RGD) is the most common peptide motif responsible for cell adhesion to the extracellular matrix (ECM). RGD is a universally used tool in the construction of multifunctional “smart” materials, such as peptide-based hydrogels, and is found in many applications in biological research and medical devices.

Biogelx™ technology is based on a two-peptide system: a hydrophobic ‘gelator’ peptide and a hydrophilic ‘surfactant’. The “surfactant” functionality of the peptide fibres can be modified to incorporate various biomimetic peptide sequences from key extracellular matrix proteins, one such peptide being RGD. The clinical potential of Biogelx hydrogel technology incorporating this cell-adhesion peptide was demonstrated in a recently published study focused on the development of a novel spinal cord repair strategy.

Biogelx’s new generation RGD functionalised bioink offers the same benefit as the company’s original RGD functionalised hydrogel product (Biogelx™-RGD), but it has been developed with printability in mind. The Biogelx™-INK-RGD prints without the need for temperature or pH adjustment, UV curing, or addition of reactive cross-linking reagents, all of which can be detrimental to the health of cells. The gelation is simply triggered by the addition of cell culture media; thus, users have complete control of the process.

Biogelx™-INK-RGD is very easy-to-handle. The product is provided as a lyophilized peptide powder and a Biogelx™-PREP solution, used to prepare the final bioink formulation.  Thanks to this easy-to-use format this bioink powder are stable for one year providing customers with no waste. Preparation of the bioink is very straightforward. Simply take the Biogelx™-INK, mix the powder with the preparation solution at room temperature, store the pre-gel solution at 40C overnight, add Ca2+containing cell culture media, incubate at 370C, and then start printing.

Biogelx™’s RGD functionalised bioink has been designed to work easily and accurately with both extrusion-based and ink-jet printers to produce high-quality and reliable prints. The controllable physical properties of this product, together with the biocompatibility of the peptide building blocks guarantees both cell viability and printability. No other RGD functionalised bioink offers the versatility to mechanically tune the matrix scaffold reliably and consistently to specific 3D cell culture applications.

Do you want to know how our new Biogelx™-INK-RGD could best support you in your research? Contact our business development manager!

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