Synthetic 3D Peptide Hydrogels Designed for Your Research Ambitions
Our novel patented 3D peptide hydrogels can be chemically and mechanically modified to mimic different tissues and provide a cost-effective, animal-free 3D matrix to support a range of exciting high growth applications including 3D cell culture, 3D bioprinting, tissue engineering & regeneration, and in vitro models for drug screening.
We offer Alternatives to Animal-Derived 3D Matrices
The core technology embedded in our commercial products is that of cooperative assembly (or co-assembly) of short self-assembling peptide amphiphiles. Typical products contain structural, fiber forming, components, and functional components, which introduce (bio-) chemical functionality to the surface of the fibers. The peptide components are composed of short (e.g. di- or tri-) peptide sequences, in some cases modified with an aromatic unit to enhance the self-assembly propensity.
Do you want to learn more? Watch our presentation on ‘Bio-Inspired Materials for 3D Cell Culture and Bioprinting’.
Our Bio-Inspired Hydrogel gives control back to you
No pH or Temperature Requirements
Biogelx’s peptide hydrogels are easy to handle and are provided as a lyophilised powder which not only means an extended shelf life but provides you with more flexibility to tune the gels to your requirements. When the Biogelx powder is added to water, the peptides self-assemble to form fibres producing what is known as a “pre-gel” solution. This pre-gel has a neutral pH and it is at this stage that cells can be encapsulated for 3D cell culture techniques. It is at this stage that cells can be encapsulated for 3D cell culture techniques. Only when this “pre-gel” solution comes in contact with calcium ions in cell culture media does gelation take place to form the final gel. The final stiffness of the gel is determined by the amount of Biogelx powder used.
Our gels Match stiffness of various tissue types
The mechanical properties of the final hydrogels can be controlled through variations in peptide concentration (i.e. fibre density) which allows tailoring to match the mechanical environment (stiffness) of various tissue types, thereby providing an optimal environment for the culture of a variety cell types. This ability to control the matrix stiffness means Biogelx hydrogels can aid stem cell migration, differentiation, survival, and integration. The stiffness of the gel matrix dictates cell fate, with soft gels favouring differentiation towards soft tissue cells (e.g. neuronal, adipose) and rigid gels favouring differentiation towards stiff tissue lineages (e.g. bone, cartilage).