Volumetric Bioprinting: A novel method for complex tissues printing


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Researchers from École Polytechnique Fédéral de Lausanne (EPFL) and the University Medical Center Utrecht are using a novel approach to address the existing speed limitation of many bioprinting technologies for the printing of complex tissues. The newly developed method called volumetric bioprinting takes only a few seconds to generate complex shapes in a biocompatible, stem-cell-laden hydrogel.

To create tissue constructs of clinically relevant size, the researchers use a cylindrical container filled with a cell‐laden photoresponsive hydrogel connected to a rotating platform. A series of 2D patterns is projected onto the cylinder, using a laser light source, triggering polymerization is specific locations. In as little as a few seconds, this spatially selective crosslinking generates the “printed” construct suspended in gel. The stem cells in the hydrogel are largely unaffected by this process.

(Credit: EPFL)

“The characteristics of human tissue depend to a large extent on a highly sophisticated extracellular structure, and the ability to replicate this complexity could lead to a number of real clinical applications,” says Paul Delrot, a co-author. “Using this technique, labs could mass-produce artificial tissues or organs at unprecedented speed. This sort of replicability is essential when it comes to testing new drugs in vitro.”

“This is just the beginning. We believe that our method is inherently scalable towards mass fabrication and could be used to produce a wide range of cellular tissue models, not to mention medical devices and personalized implants,” says Christophe Moser, the head of the LAPD.

Read the full article here: https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201904209

 

Source: Paulina Nuñez Bernal et al. Volumetric Bioprinting of Complex Living‐Tissue Constructs within Seconds, Advanced Materials (2019).

 

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